By Fabio Giuseppe Carlo Carisio - July 30, 2022
Analysis & Care by BMJ
«In this meta-analysis with parametric cure modeling of time-to-event data from 3699 patients in 18 studies, we identified a major burden of long-term self-reported smell and taste abnormalities, with about 5% of patients developing persistent dysfunction. This outcome might contribute to the growing burden of long Covid».
According to the analysis of researchers from the University of Singapore published in recent days by the British Medical Journal 5% of Covid patients still suffer from anosmia or ageusia. In another study, the therapies were suggested by three Italian medical specialists.
This was written by Professor Benjamin Kye Jyn Tan of the Yong Loo Lin School of Medicine, the National University of Singapore, together with other Asian researchers in a research published on July 27 by the British Medical Journal and subsequently analyzed in a scientific editorial by three Italian specialists. (link to the studies in English at the bottom of the article).
The study takes on an even more alarming value when it highlights the risks associated with these consequences of SARS-Cov-2 infection.
«These factors raise important clinical questions relevant to patients and doctors, as persistent smell and taste dysfunction could be considered a focal neurological deficit and can have an impact on quality of life and general health long after recovery from covid-19. Affected patients are often distressed as these impairments can hinder the enjoyment of food and create hygiene problems related to body odor and bad breath. Smell and taste dysfunctions might also be associated with depressive symptoms, malnutrition, cognitive decline, and mortality».
«Change in the sense of smell and taste is highly prevalent in patients with covid-19, with 40-50% of people on average reporting these symptoms globally, and up to 98% showing olfactory dysfunction when tested objectively. These chemosensory impairments are often the sole warning symptoms and the strongest predictors of SARS-CoV-2 infection. Disturbances in these senses can include decreased (hyposmia or hypogeusia) or absent function (anosmia or ageusia), distorted (parosmia or parageusia), or putrid sensations (cacosmia or cacogeusia), or even hallucinations (phantosmia or phantogeusia)» it is further explained in the research.
But above all, Professor Tan and the other specialists note a truly disturbing aspect: «In the context of covid-19, smell dysfunction has been postulated as a possible marker of accelerated neurodegenerative disease, and this symptom is an important feature of long covid».
LONG COVID AND DNA ALTERATION BY SARS-2 BIO-WEAPON
This consideration brings to mind the reflections of the German geneticist Walter Doerfler from Cologne who in his study on DNA-based gene sera (AstraZeneca and J&J) and messenger RNA (Pfizer-Biontech and Moderna) confirmed the probability that they could modify human DNA (as also recently reiterated by a scientist of the famous MIT – Massachusetts Institute of Technology in Cambridge) but at the same time highlighted that SARS-Cov-2 itself could involve the same genetic alterations, effectively legitimizing all the theses of authoritative virologists and experts of intelligence on the artificial origin of this virus as a bacteriological weapon with a viral load enhanced by a highly toxic Spike protein.
A Science article also confirmed multiple similarities between the Long Covid of the infected and those similar forms developed by the vaccinated for adverse reaction to gene sera.
Research conducted by the French biologist Luc Montagnier, Nobel Prize for Medicine in 2008, and published posthumously after his death by his collaborators, has finally well explained the connections between the dangerous prions created by the Spike protein of vaccines and neurodegenerative diseases.
This is why what the medical researcher of the University of Singapore has written takes on a disruptive value even if it implies a basic limitation: «As the pandemic has evolved over time, particularly with respect to vaccines, treatments, lockdowns, masks, and variants, the inherent clinical and methodological heterogeneity of the included studies might limit generalization».
This variable danger and lethality of the pathogen were well explained by the French bio-engineer Pierre Bricage, NATO consultant and expert in bacteriological weapons, in relation to the construction in the laboratory of the Covid-19 virus, now also supported by the president of the Covid-19 Commission of the famous British scientific journal The Lancet, Jeffrey D. Sachs, and supported with genetic evidence by an international study also signed by the Italian virologist Giorgio Palù, president of the Italian Medicines Agency (AIFA).
But all these considerations, obviously, should be analyzed in necessary multi-specialist medical investigations that at the moment we do not know have yet been conducted and, therefore, the hypothetical correlation between neurological dysfunctions from Long Covid and genetic alterations from toxic Spike is only our free scientific speculation…
Let’s see what the two studies published by BMJ write in detail.
WOMEN MOST EXPOSED TO THE RISK OF LOSS OF TASTE
«Women were less likely to recover their sense of smell and taste. Patients with higher initial severity of dysfunction and patients with nasal congestion were also less likely to recover their sense of smell. While most patients are expected to recover their sense of smell or taste within the first three months, a major subpopulation of patients might develop long-lasting dysfunction. These patients require timely identification, personalized treatment, and long-term follow-up for associated sequelae. Our findings are likely to be of substantial relevance to general doctors and otolaryngologists in the counseling of patients with smell and taste disorders post-covid-19».
Professor Tan and the other Singaporean researchers added, grasping the heart of the problem because three Italian doctors with specialized skills in discomfort immediately prepared an illuminating editorial.
«The linked meta-analysis by Tan and colleagues gives a clear picture of the challenge humans face. About 5% of people report smell and taste dysfunction six months after covid-19, and, given that an estimated 550 million cases of covid-19 have been reported worldwide as of July 2022, large numbers of patients will be seeking care for these disabling morbidities. Health systems should therefore be ready to provide support to these patients who often report feeling isolated when their symptoms are overlooked by clinicians».
This is what was written by academics Paolo Boscolo-Rizzo, Professor of Otolaryngology at the Department of Medical, Surgical and Health Sciences of the University of Trieste, Jerry Polesel of the Cancer Epidemiology Unit, Oncological Reference Center of Aviano ( CRO) IRCCS, and Luigi A Vaira, maxillofacial surgeon of the Department of Medical, Surgical and Experimental Sciences of the University of Sassari.
According to their calculation, in the world, there would therefore be about 27.5 million people still afflicted by a similar dysfunction from Long Covid.
«The treatment of chemosensory disorders is still frustrating, as few evidence-based options are available. Knowing the pathogenetic mechanisms of SARS-CoV-2-induced olfactory loss can provide a more solid basis for the development of new treatment strategies. Although the involvement of the olfactory bulb and central olfactory pathways cannot be excluded, most evidence points to the virus targeting supporting cells of the olfactory neuroepithelium. These cells—not olfactory neurons—express the molecular make-up necessary for entry of the virus».
«One recent high-quality study suggests that viral or cellular components released from infected supporting cells cause widespread downregulation of olfactory receptors and of their signaling components in olfactory sensory cells. Thus, the primary target of the treatment for post-covid-19 anosmia should be the olfactory neuroepithelium» add the doctors who then suggest some therapeutic methods, without however mentioning vaccines as a weapon of protection against this disorder.
TO FIND THE TASTE: OLFACTORY TRAINING AND STEROIDS
«Olfactory training started as soon as possible after the onset of symptoms is the only disease-specific intervention with evidence of efficacy for the treatment of post-infectious olfactory dysfunction. First proposed by Thomas Hummel in 2009, olfactory training exploits the unique regenerative capabilities of the olfactory neuroepithelium. Patients are advised to sniff and try to identify a sequence of four strong smelling scents—usually rose, eucalyptus, lemon, and clove—for 15 seconds twice a day over the course of several months» we can still read in the text published on BMJ by Professor Boscolo-Rizzo and colleagues Polesel and Vaira.
«In addition to the use of nasal steroids, which aim to resolve SARS-CoV-2 induced inflammation, other treatments that have shown some, albeit marginal, benefit in small clinical trials include intranasal vitamin A and supplements of alpha lipoic acid and omega 3 fatty acids. As olfactory neuroepithelium is located in the hidden posterior roof of the nasal cavity, specific delivery systems able to distribute drugs to the olfactory region could improve the efficacy of intranasal treatment options».
«A large number of people with long-lasting chemosensory dysfunction after covid-19 offers a unique opportunity to test new treatments in large multicentre trials. Health leaders, policymakers, and research funders should realize the extraordinary importance of good chemosensory function for the wellbeing of humans, allocate adequate resources to support chemosensory research, and sustain medical specialists faced with an exceptional number of patients with smell and taste dysfunction» conclude the doctors who in their analysis also pointed out the danger of this disorder.
«Numerous studies have consistently observed that subjective evaluation tends to underestimate the real prevalence of olfactory dysfunctions compared with psychophysical tests. Using pen-like odor dispensing devices, these psychophysical tests can measure odor thresholds as well as olfactory discriminative and identification abilities. In a recent case-control study of patients one year after covid-19, we observed that participants who self-reported complete resolution of their loss of smell had statistically significantly lower psychophysical olfactory scores than people with no history of covid-19 matched on sex and age» medical academics added.
«Although an unconscious alteration of the sense of smell may not impact the quality of life, it exposes people to possible risks. In addition to eating behavior, nutrition, and social communication, both smell and taste are crucial for vital functions such as warning against environmental hazards, including fires, poisonous fumes, leaking gas, and spoiled food» this is the final important point of the Italian study published by the British Medical Journal.
Fabio Giuseppe Carlo Carisio
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Fabio Giuseppe Carlo Carisio
Fabio is the Director and Editor of Gospa News; a Christian Information Journal.
Fabio Giuseppe Carlo Carisio, born on 24/2/1967 in Borgosesia, started working as a reporter when he was only 19 years old in the alpine area of Valsesia, Piedmont, his birth region in Italy.
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