US Grant To Wuhan Lab To Enhance Coronaviruses Was Never Scrutinized By HHS Review Board

By ANDREW KERR - INVESTIGATIVE REPORTER - April 04, 2021

• The National Institutes of Health has “systematically thwarted” government oversight of dangerous pathogen research, Rutgers University professor of chemical biology Richard H. Ebright told the Daily Caller News Foundation.
• The P3CO Review Framework was created in 2017 after a three-year pause on government funding of research that intentionally makes pathogens more deadly or transmissible.
• An NIH grant that involved the modification of bat-based coronaviruses and the transfer of $600,000 to the Wuhan Institute of Virology prior to the pandemic bypassed P3CO review because the National Institute of Allergy and Infectious Diseases, led by Anthony Fauci, didn’t flag the project for review.

An oversight board created to scrutinize research that would enhance highly dangerous pathogens did not review a National Institutes of Health grant that funded a lab in Wuhan, China, to genetically modify bat-based coronaviruses.

Experts say the NIH grant describes scientists conducting gain-of-function research, a risky area of study that, in this case, made SARS-like viruses even more contagious. Federal funding for gain-of-function research was temporarily suspended in 2014 due to widespread scientific concerns it risked leaking supercharged viruses into the human population.

Federal funding for gain-of-function research was resumed in late 2017 after the Potential Pandemic Pathogens Control and Oversight (P3CO) Framework was formed within the Department of Health and Human Services (HHS). The review board is tasked with critically evaluating whether grants that involve enhancing dangerous pathogens, such as coronaviruses, are worth the risks and that proper safeguards are in place.

But the NIH subagency that awarded the grant to the nonprofit group EcoHealth Alliance to study Chinese bat coronaviruses opted against forwarding it to the P3CO committee, an NIH spokesperson told the Daily Caller News Foundation, meaning the research received federal funding without an independent review by the HHS board.

“This is a systemic problem,” Rutgers University professor of chemical biology Richard H. Ebright told the DCNF, referring to the loophole in the review framework.

Ebright said the offices of the director for the National Institute of Allergy and Infectious Diseases (NIAID) — the subagency that funded EcoHealth — and the NIH have “systematically thwarted–indeed systematically nullified–the HHS P3CO Framework by declining to flag and forward proposals for review.”

Dr. Anthony Fauci leads the NIAID and Dr. Francis S. Collins heads the NIH.

An NIH spokesperson said its subagency did not flag the EcoHealth grant for independent review by the HHS review committee.

“After careful review of the grant, NIAID determined research in the grant was not gain-of-function research because it did not involve the enhancement of the pathogenicity or transmissibility of the viruses studied,” the spokesperson told the DCNF.

“We would not submit research proposals that did not meet the definition, because otherwise we would need to submit everything,” the spokesperson said.

How Federal Oversight Of Gain-Of-Function Research Is Bypassed

The Wuhan Institute of Virology (WIV) is at the center of widespread speculation that COVID-19 could have accidentally leaked from a lab into the human population. EcoHealth’s grant to study bat-based coronaviruses in China included the transfer of $600,000 to the WIV.

Had EcoHealth’s grant been subjected to P3CO review, an HHS panel would have independently evaluated the grant and, if necessary, recommended additional biocontainment measures to prevent potential lab leaks — or even recommended that the grant be denied entirely.

The WIV is a biosafety level 4 laboratory, the highest level biocontainment certification, but U.S. Embassy officials issued two diplomatic cables warning about inadequate safety at the lab after a visit in 2018. One of the cables warned that the lab’s work on bat-based coronaviruses represented the risk of a new SARS-like pandemic, according to The Washington Post.

An annex to the World Health Organization’s COVID-19 origin report released Tuesday describes the WIV’s work using “recombinant viruses” in tests involving bat coronaviruses, which Ebright said are descriptions of gain-of-function research.

The U.S. government paused funding of gain-of-function research in 2014 after lab workers were accidentally exposed to anthrax by the Centers for Disease Control, according to The New York Times. The incident came on the heels of widespread scientific outcry in 2011 when it was revealed that laboratories in Wisconsin and the Netherlands were intentionally modifying the H5N1 bird flu virus so it could more effectively jump between ferrets.

Dr. Anthony Fauci, Director of the National Institute of Allergy and Infectious Diseases, speaks during a White House press briefing, conducted by White House Press Secretary Jen Psaki, at the James Brady Press Briefing Room of the White House January 21, 2021. (Photo by Alex Wong/Getty Images)

Federally funded gain-of-function research resumed in 2017 after new oversight procedures were implemented. The review framework split oversight responsibilities between two groups — the funding agency (the NIAID in the case of the EcoHealth grant) and the P3CO Review Committee, an interdisciplinary group convened by HHS.

The committee is responsible for recommending whether a research grant involving gain-of-function needs to include any additional risk mitigation measures, an HHS spokesperson told the DCNF. But the committee is kept in the dark on any grant until the funding agency flags one for its review.

The P3CO Framework doesn’t require the HHS review committee to take a second look at the NIAID’s determination following its review that the EcoHealth grant did not involve gain-of-function research.

The NIH spokesperson said it would be “misleading and inaccurate” to suggest NIAID was required to notify the HHS review committee of its determination.

An HHS spokesperson confirmed that the department’s P3CO Review Committee only reviews research grants that are flagged for additional review by funding agencies such as NIAID. The spokesperson did not answer when asked if the review committee had knowledge of the EcoHealth grant.

Ecohealth has a history of manipulating bat-based coronaviruses. The group’s president, Peter Daszak, said as much during a podcast interview filmed in Singapore just weeks before the first reported cases of COVID-19 in Wuhan in December 2019.

“You can manipulate them in the lab pretty easily,” Daszak said. “Spike protein drives a lot of what happens with the coronavirus. Zoonotic risk. So you can get the sequence, you can build the protein — and we work with Ralph Baric at [the University of North Carolina] to do this — and insert the backbone of another virus and do some work in the lab.”

Ebright told the DCNF that NIAID was wrong to determine that the EcoHealth grant did not involve enhancing the transmissibility of Chinese bat-based coronaviruses. He said the project’s abstract for the 2019 fiscal year, which referenced “in vitro and in vivo infection experiments” on coronaviruses, “*unequivocally* required risk-benefit review under the HHS P3CO Framework.”

Other scientists have said EcoHealth’s NIH-funded work in China involved gain-of-function research on bat-based coronaviruses.

“It is hard to overemphasize that the central logic of this grant was to test the pandemic potential of SARS-related bat coronaviruses by making ones with pandemic potential, either through genetic engineering or passaging, or both,” Drs. Jonathan Latham and Allison Wilson wrote in June.

The NIH terminated the EcoHealth grant in April 2020. NIH deputy director for extramural research, Michael Lauer, told the group in a letter that the agency “does not believe that the current project outcomes align with the program goals and agency priorities.”

Fauci said during a hearing before the House Energy & Commerce Committee in June that the EcoHealth grant was canceled “because the NIH was told to cancel it.”

“I don’t know the reason, but we were told to cancel it,” Fauci said.

Fauci told Politico following the hearing that former President Donald Trump’s White House ordered the NIH to cancel the grant.

HHS Official Acknowledged Government Oversight Of GOF Research Is Flawed

The only known member of the HHS P3CO Review Committee is its chairman, Chris Hassell, the senior science advisor for the HHS Office of the Assistant Secretary for Preparedness and Response. He disclosed his involvement in a January 2020 talk before the National Science Advisory Board for Biosecurity.

Hassell said during the talk that the current definition for a potential pandemic pathogen is “very narrow … which has resulted in only getting a few influenza-related proposals” for the committee’s review.

“I’ll just probably be more frank than maybe appropriate — I think that’s too narrow,” said Hassell, who then suggested that the government could be funding gain-of-function research that his committee hasn’t vetted.

“I think that could be revisited, and again there could be some definition issues,” Hassell said.

When gain-of-function funding was paused in 2014, 21 research projects were halted. But the NIH created exceptions for 10 of those, according to The New York Times.

After the funding continued in 2017, only two projects have been approved in accordance with the P3CO Framework. Both projects deal with the influenza virus, according to the NIH.

It’s unclear how many research grants have been reviewed under the framework. An NIH spokesperson said they don’t comment or discuss unfunded grant applications.

It’s also unclear who else serves on the HHS P3CO Review Committee. Hassell said in January 2020 that the committee is comprised only of federal employees, but said it could be detrimental to their work to release their names.

“As much as it would be good to publicize the individual names, which has been suggested, if that chills anyone being willing to serve on that committee, that would be detrimental,” Hassell said.

An HHS spokesperson said Hassell was unavailable for comment.

Eleanor Bartow contributed to this report.

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Video: Rand Paul Continues Fauci Feud; "He Could Be Culpable For The Entire Pandemic"

BY TYLER DURDENTHURSDAY, MAY 13, 2021 - 03:00 PM

Authored by Steve Watson via Summit News (emphasis ours)

Senator Rand Paul continued to slam White House medical advisor Thursday, saying that Anthony Fauci could be culpable for the entire coronavirus pandemic.

Paul was attacked by leftist media Wednesday for merely questioning Fauci’s extensive role in granting funding to the Wuhan Institute of Virology at a Senate hearing.

CNN’s Anderson Cooper declared that Paul should “have more respect at least for medical science.”

Paul hit back, noting that Fauci is lying about the NIH’s involvement in funding of the Wuhan lab.

Now in a further appearance on Fox And Friends, Paul has gone even deeper, accusing Fauci of being personally to blame for the global pandemic.

“The person they hired to investigate the lab for the WHO perspective is the guy who gave the money,” Paul urged.

“So NIH gave the money to EcoHealth. The head of EcoHealth – they got him to investigate whether Wuhan was doing anything inappropriate in their lab. But if they were then wouldn’t he be culpable?” The Senator questioned.

“Doesn’t he have a self interest in smoothing things over,” Paul continued, adding “I’m not saying he did cover things up but you wouldn’t appoint someone who is in the line of the supply chain of giving the money to them.”

“Ultimately here’s the rub. I don’t know whether it came from the lab. But who could be culpable? Dr. Fauci could be culpable for the entire pandemic!” Paul emphasised.

Watch:

As Infowars reported in April 2020, the NIH awarded a $3.7 million grant to the Wuhan Institute of Virology to conduct coronavirus gain of function research.

Additionally, the results of the US-backed gain of function research at Wuhan was published in 2017 under the heading, “Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus.”

Fauci has come under increased scrutiny as the NIH’s involvement with the Wuhan lab is being called into question.

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